ABSTRACT
OBJECTIVE: To establish a method for determining arsenic (As) and antimony (Sb) released from pharmaceutical glass packing materials to provide reference for improving the existing quality standard. METHODS: The samples were filled with 4% acetic acid to leach As and Sb. The extracting temperature was 98℃, and the extracting time was 2 h. Graphite furnace atomic absorption spectrometry (GFAAS) was used for the determination. RESULTS: As and Sb showed good linear relationship in a certain concentration range with linear correlation coefficients of 0.999 9 and 0.999 5. The recovery rates were 94.7%-106.9% and 100.0%-106.3%. The relative standard deviations of precision were 2.3% and 2.9%. The relative standard deviations of repeatability were 6.5% and 6.9%. The limits of detection were 1.67 and 2.54 ng·mL-1, respectively. The elements were nearly not detected in 16 batches of samples. CONCLUSION: The method is efficient and accurate and can be used for determination of As and Sb released from pharmaceutical glass packing materials, which brings supplementary contents to the existing quality standard.